646 S 2nd St

Louisville, KY 40202

Apartment building

2-3 beds

Available units

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To contact, request a tour, or apply, select a unit below. Each unit has its own contact details.

Price may not include required fees and charges.

Unit , sortable column	Sqft, sortable column	Available, sortable column	Base rent, sorted ascending
Unit 6 2 bd, 2.5 ba	1,816	Now	Fees may apply $1,700
Unit 4 2 bd, 2.5 ba	1,832	Now	Fees may apply $1,900

Neighborhood: Central Business District

Areas of interest

Use our interactive map to explore the neighborhood and see how it matches your interests.

Travel times

Getting around

Walk Score^®

/ 100

Very Walkable

Bike Score^®

/ 100

Very Bikeable

Nearby schools in Louisville

Engelhard Elementary School

Grades K-5 • 0.7 miles

9/10

GreatSchools^® Rating

Academic Progress Rating

9/10

Highland Middle School

Grades 6-8 • 3.2 miles

5/10

GreatSchools^® Rating

Test Score Rating

4/10

Academic Progress Rating

6/10

Eastern High School

Grades 9-12 • 12.5 miles

5/10

GreatSchools^® Rating

Test Score Rating

5/10

College Readiness Rating

5/10

Historic Area
The Seelbach Hilton and other historic downtown buildings give the district a strong sense of Louisville’s past.
Outdoor Activities
Waterfront Park and the Ohio River Greenway provide paths and riverfront space for time outdoors.
Dining Scene
Restaurants and cafés are woven through the downtown blocks, especially around Fourth Street Live!.
Transit Access
TARC buses and the area’s walkable street grid make it easier to get around without relying only on a car.

Louisville’s Central Business District sits along the Ohio River, where historic downtown blocks meet the waterfront and the city’s larger urban grid. The Ohio River Greenway and Waterfront Park offer open-air paths, river views, and places to pause outdoors; playgrounds and the Louisville Free Public Library’s Main Library add recreation and reading options nearby. The area’s built character ranges from the ornate Seelbach Hilton to the glass-fronted offices around Fourth Street Live!, with theaters, galleries, restaurants, coffee shops, and evening venues concentrated downtown. Shops and everyday services are woven among civic and cultural destinations. The street grid makes walking practical, while TARC buses and nearby highway connections link downtown with other parts of Louisville. The Central Business District’s median rent is $1,800 per month, with a typical range of $936 to $2,800, based on 14 active listings.

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Frequently asked questions

Where is 646 S 2nd St located, and what is the neighborhood like?

646 S 2nd St is located at 646 S 2nd St in Central Business District, Louisville, KY. The surrounding area includes multiple restaurants and cafes within 2 miles, such as J Graham's Cafe, Brendon's Catch 23, and Heine Brothers' Coffee - Fourth Street Live.

What hospitals and medical facilities are near 646 S 2nd St?

The closest hospitals and medical facilities to 646 S 2nd St include KentuckyOne Health Jewish Hospital Rudd Heart and Lung Center (0.3 miles away), KentuckyOne Health Jewish Hospital (0.3 miles away), and Shea Orthopedic Group (0.3 miles away).

What schools are assigned to 646 S 2nd St?

The schools assigned to 646 S 2nd St include Engelhard Elementary School, Highland Middle School, and Eastern High School.

What are the grocery stores and everyday shopping options near 646 S 2nd St?

646 S 2nd St is located near 1 grocery store, including Locals Food Hub & Pizza Pub (0.9 miles). Additional shopping options, including Block Party Handmade Boutique, are approximately 0.2 miles away.

What colleges and universities are near 646 S 2nd St?

646 S 2nd St is located within 0.1 miles of JCTC Allied Health Bldg, 0.2 miles of JCTC, and 0.3 miles of Spalding University.