Unlock the potential of 621 Main Street, Lewiston, Maine, a highly visible mixed-use property offering outstanding flexibility for business owners, investors, and entrepreneurs. Positioned along one of Lewiston's well-traveled corridors, this property benefits from excellent exposure, strong daily traffic counts, and convenient access to downtown amenities and major commuter routes.
The first floor features adaptable commercial space ideal for retail, office, professional services, creative studios, wellness practices, or a variety of other business uses. Prominent street frontage enhances visibility and signage opportunities, helping your business stand out and attract customers.
A major value-add is the spacious second floor, offering the potential to create a private owner's residence, employee housing, or an income-producing rental unit (subject to local approvals). The live-work flexibility creates a unique opportunity to reduce overhead, generate additional revenue, or maximize the property's investment potential.
Additional highlights include ample off-street parking, excellent accessibility, and a location surrounded by established businesses, restaurants, and neighborhood services.
Whether you're seeking a new headquarters for your business, a mixed-use investment, or a property with future development possibilities, 621 Main Street delivers visibility, versatility, and long-term upside in the heart of Lewiston.
Schedule your showing today and explore the possibilities this unique property has to offer.
Also listed as MLS# 1662884
Active
$499,000
621 Main Street, Lewiston, ME 04240
4beds
2,000sqft
Single Family Residence
Built in 1906
7,405 Square Feet Lot
$-- Zestimate®
$250/sqft
$-- HOA
What's special
Adaptable commercial spaceSpacious second floorProminent street frontageAmple off-street parking
- 39 days |
- 286 |
- 6 |
Likely to sell faster than
Zillow last checked:
Listing updated:
Listed by:
Signature Homes Real Estate Group
Source: Maine Listings,MLS#: 1662959
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Facts & features
Interior
Bedrooms & bathrooms
- Bedrooms: 4
- Bathrooms: 2
- Full bathrooms: 1
- 1/2 bathrooms: 1
Bedroom 1
- Level: Second
Bedroom 2
- Level: Second
Bedroom 3
- Level: Second
Bedroom 4
- Level: Second
Dining room
- Level: First
Kitchen
- Level: First
Living room
- Level: First
Mud room
- Level: First
Heating
- Radiator
Cooling
- Other
Appliances
- Included: Microwave
Features
- Attic
- Flooring: Wood
- Basement: Interior Entry,Full,Brick/Mortar,Unfinished
- Number of fireplaces: 1
- Furnished: Yes
Interior area
- Total structure area: 2,000
- Total interior livable area: 2,000 sqft
- Finished area above ground: 2,000
- Finished area below ground: 0
Property
Parking
- Parking features: Paved, 1 - 4 Spaces, Off Street
Features
- Patio & porch: Porch
Lot
- Size: 7,405 Square Feet
- Features: Near Shopping, Near Turnpike/Interstate, Near Town, Neighborhood, Level, Open Lot, Landscaped
Details
- Parcel number: LEWI000192000000000046
- Zoning: NB
Construction
Type & style
- Home type: SingleFamily
- Architectural style: Dutch Colonial,Mansard
- Property subtype: Single Family Residence
Materials
- Wood Frame, Clapboard, Shingle Siding, Wood Siding
- Foundation: Stone, Brick/Mortar
- Roof: Shingle
Condition
- Year built: 1906
Utilities & green energy
- Electric: Circuit Breakers
- Sewer: Public Sewer
- Water: Public
Community & HOA
Location
- Region: Lewiston
Financial & listing details
- Price per square foot: $250/sqft
- Annual tax amount: $3,780
- Date on market: 5/20/2026
Estimated market value
Not available
Estimated sales range
Not available
Not available
Price history
| Date | Event | Price |
|---|---|---|
| 5/20/2026 | Listed for sale | $499,000$250/sqft |
Source: | ||
Public tax history
Tax history is unavailable.
Monthly payment
Est. payment$--/mo
Payment breakdown
Explore the cost of this home by adjusting the details. Changes won't be saved.All calculations are estimates and provided by Zillow, Inc. for informational purposes only. Actual amounts may vary.
HOA fees may include property taxes on listings classified as Co-Ops. Contact the listing agent and/or owner for fee details.
Mortgage interest rates are dependent on a number of factors, including credit score, down payment, and repayment length. Interest rate data provided by Zillow Group Marketplace, Inc. as of 1/1/1970 from various mortgage lenders with which we have lead or other similar arrangements; the Estimated Payment is an average of those rates.
See how much you could borrow to make a competitive offer.
Climate risks
Neighborhood: 04240
Nearby schools
GreatSchools rating
- 2/10Raymond A. Geiger Elementary SchoolGrades: PK-6Distance: 1 mi
- 1/10Lewiston Middle SchoolGrades: 7-8Distance: 1 mi
- 2/10Lewiston High SchoolGrades: 9-12Distance: 1.8 mi
A local agent can set up tours, give advice and negotiate with sellers.
- Maine
- Androscoggin County
- Lewiston
- 04240
- 621 Main Street






